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VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN
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DeCS
Descriptor
English
:
Von Hippel-Lindau Tumor Suppressor Protein
Descriptor
Spanish
:
Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau
Descriptor
Portuguese
:
Proteína Supressora de Tumor Von Hippel-Lindau
Tree Number:
D08.811.464.938.750.875
D12.776.624.776.865
Definition
English
:
A
ubiquitin-protein ligase
that mediates OXYGEN-dependent polyubiquitination of
HYPOXIA-INDUCIBLE FACTOR 1
, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU
SYNDROME.
Entry Combination - descr/qualif
English
:
Von Hippel-Lindau Tumor Suppressor Protein
/
deficiency
use
von Hippel-Lindau Disease
History Note
English
:
2006(1995)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50588
Unique Identifier:
D051794
Occurrence in VHL
:
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DeCS
CID-10
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